More ground level clinical views by a local news site: […], […] Dexamethasone for COVID – The RECOVERY Trial; First10EM […], […] You can read more here.
But the news media is in a crisis of its own. But, assuming such factors will be unconvincing to those who believe that a country’s support for hydroxychloroquine is determinative, I am curious how they explain Brazil? We also noticed a couple of negative reports about CQ and HCQ (Geleris et al., 2020; Mahevas et al., 2020; Magagnoli et al., 2020).
do i need to go into more nuance?
Not saying Bolsonaro knows anything about the effectiveness of HCQ but he hit the nail on the head when he criticized the New England Urinal of Medicine studies lol! That’s right Some idiot if you can’t win the argument just insult the other person and run away. Think of it this way.
Of 2,541 patients, with a median total hospitalization time of 6 days (IQR: 4-10 days), median age was 64 years (IQR:53-76 years), 51% male, 56% African American, with median time to follow-up of 28.5 days (IQR:3-53). None: median:71, 25percentile:56, 75percentile:83 However, correlation is not causation.
Interesting if you look at Table 1… the hospitalized patients not on O2 were much older and somewhat more comorbid. Received April 23, 2020; accepted May 12, 2020; published online May 15, 2020 That didn’t age well. 19 of the 20 studies show that it does not help.
var notice = document.getElementById("cptch_time_limit_notice_11"); Further, prevention and treatment studies in non-human primates showed it reduced the amount of virus and associated damage in the lungs. Please see our, This trial is supported by a grant to the University of Oxford from, National Institute for Health Research (NIHR, Medical Research Council Population Health Research Unit. Here are the summary results for percent positive results: Works faster doing whatever he thinks it’s supposed to do I guess.
Things got very dire and if you came down with the flu they came and took you away to a field hospital. No eye disease was detected in over 900 rheumatoid arthritis patients treated with less than 4.0 mg/kg per day of chloroquine or less than 6.5 mg/kg per day of hydroxychloroquine for a mean of about seven years. Quercetin is another known zinc ionophore like HCQ. So, to me, the paper still looks to be wrong in its conclusions. What is the state of the story with Covid-19 and nicotine? Anyone else writing an abstract would! The RECOVERY trial (which stands for ‘Randomised Evaluation of COVid-19 thERapY’) was funded by UKRI as part of the UKRI/DHSC/NIHR COVID-19 rapid research response. In that context, the RECOVERY trial results are enough to convince me that all critically ill COVID patients (those requiring oxygen support) should be given dexamethasone for the time being, but that these results should still be followed with a properly blinded RCT. Last night, the Committee recommended the chief investigators review the unblinded data on the hydroxychloroquine arm of the trial. That’s an EARLY treatment protocol he was recommending.
Am I missing something fundamental here, or are this paper’s conclusions the garbage that they look like? Either they are complicit in a massive conspiracy for unknown reasons or the rot (ineptitude and corruption) in the medical research community runs deeper than we think. Did anyone else notice that the fatality rates in Utah which started using HCQ early and widely are unusually low? there are two phases of the covid syndrome first cold like symptomes and the Raoult data show us that low doses of Hydr + low doses of Azi blocked the viral shedding (at the moment nobody have tested this with rcts but you had observational study). What information do you hold about me and how do you keep it private? I apllaude you for your HCQ workaround with quercetin.
So RA to coin a phrase from the climate change fraud, is the science settled?
Let’s all hope against hope that early HCQ does NOT work. The anti-inflammatory steroid being touted as new Covid treatment hope, Why vaccines are a better bet against coronavirus than drugs, With 83,809 new Covid cases, India’s tally zooms past 49 lakh, Trump’s top aide admits US can’t control Covid pandemic, Biden says govt waving white flag, AstraZeneca-Oxford Covid vaccine produces strong immune response in older adults, Daily deaths from Covid-19 fall below 500 first time in over 3 months, recovery rate crosses 90%, China spread virus, India gave fitting reply — Aaj Tak, News18 looks for Chinese army in Noida, Mukesh Ambani and Jeff Bezos are set for a face-off over who gets Future Retail, Self regulation code by Netflix, Disney+Hotstar & Amazon Prime runs into troubles with govt. Led by Jai “Tropical Trump” Bolsonaro who is pushing hydroxychloroquine hard, Brazil is not doing well at all. The one “positive” study has exciting results so that it is published. Here is study that HCQ can be effective under a severe disease condition using low dosages comparable to those commonly taken by lupus patients: Low dose of hydroxychloroquine reduces fatality of critically ill patients with COVID-19. Might help against the cold and the flu, too. The end is nigh folks….
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They have been getting better lately since Bolsonaro fired his Minister of Health who had opposed HCQ use like Fauci. *************** The FDA determined that oral formulations of HCQ and CQ are unlikely to be effective in treating COVID-19, nor is it reasonable to believe that the known and potential benefits of these products outweigh their known and potential risks. Treatment with Hydroxychloroquine Cut Death Rate Significantly in COVID-19 Patients, Henry Ford Health System Study Shows July 2 2020, https://www.ijidonline.com/article/S1201-9712(20)30534-8/fulltext. “Keep an eye on Brazil’s deaths to recoveries ratio on Worldometer. What I will say is that common sense would clearly suggest that smokers are much more likely to be at a greater risk given what smoking does to the lungs with regards (tarring etc. Well, one of them has. Big difference.
Is that what you are saying? Professor Martin Landray, from the Nuffield Department of Population Health at the University of Oxford, and deputy chief investigator on the trial, said: “There has been huge speculation and uncertainty about the role of hydroxychloroquine as a treatment for COVID-19, but an absence of reliable information from large randomised trials.
}, I can’t image the pressure on those in your field to not use HCQ.
No large adverse safety signal from HCQ re torsades although the QTc was monitored.
This is what would be expected as occured in Raoult's and Zelenko's findings as evidenced by Yale Professor of Epidemiology Harvey Risch PhD. They started the trial by only including adult patients, but part way through opened it to all age groups (although in this draft they don’t tell us how much children were actually included).
(Of course, we should always be careful in interpreting subgroup analyses, but these results were predicted, and therefore relatively believable.). There, asymptomatic or people with wild symptoms isn’t tested and therefore don’t add to cases.
); Being a pragmatic trial, we are missing a lot of the granular detail we would love to see. The other thing that seemed strange about the paper is that the hazard ratio for white race was 1.738 (even higher than that for chronic kidney disease!). Smokers are used to reduced oxygen concentration therefore may have less sensitivity to the action of the virus. What about the fact that Landray says that the products tested is used to treat diarrhea, whereas HCQ has never been indicated for this? Though, those who claim that the rapid retraction of the Lancet and NEJM Surgisphere papers are proof of dysfunctionality and corruption are missing the point. The fact that the trial is based on 4 times the recommended prescription (500mg a day usually) at a level that is considered to be an overdose which requests hospitalisation on its own…
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HCQ works by preventing the virus from binding to and entering the cell.
The facts will reveal the truth. 4 This paper (https://academic.oup.com/jac/advance-article/doi/10.1093/jac/dkaa191/5849074) explains the rationale for a loading dose of HCQ in the COVID-19 trials: “In the case of hydroxychloroquine, the desired target concentration might be the EC50 against SARS-CoV-2 (242 ng/mL) and we used the volume of distribution (5522 L) for a calculated loading dose of approximately 1336 mg at Day 1.”, Also the problem is that HCQ has a very slow onset of action:
Age also explains why AZM+HCQ did much worse than HCQ alone (there’s a 9 year age gap between those groups). So, you apparently have difficulty in subtracting 54 from 106?
Are Medicinal Chemists Taking It Too Easy? Perhaps some of the tendency to harm is that you must think what sort of patient gets admitted for a condition with no proven treatment without hypoxia? https://www.jurist.org/news/2020/06/fda-revokes-emergency-use-authorization-for-2-medications-to-treat-covid-19/, @Bill M.
2020;192(20):E536-E545. = Do you think they are capable of doing that?
This open label RCT demonstrates a mortality benefit from dexamethasone in COVID. Although I personally believe the Sars Cov 2 threat for healthy people has been greatly exaggerated, I’m still taking zinc + quercetin supplements and plan to do so all winter. Should have something like 500 people, but better yet, 1,000.
Indian reservations in Utah might tend to offset that effect , however. IV C at 1000 mg C per kg body mass TID, with 50,000 iu vitamin D and more zinc+quercetin is our first standby for acute CV19. “Additionally, lower plasma levels of IL-6 after HCQ treatment are highly correlated with the application period of HCQ. a petition signed by 500,000 French doctors
(There were also patients that were missed simply because dexamethasone wasn’t available in the hospital.) Give the HCQ treatment EARLY like say Bahrain does. Are you only interested in the cheap treatments promoted by Trump?
“The interesting thing about our study is that fenofibrate actually binds and activates the very site on the DNA that the virus shuts down — a part of our DNA that allows our cells to burn fat,” he stated. Your email address will not be published. Big pharma have huge influence in all national health institutions in Europe and US and other countries such as Brazil which is the reason for the ridiculous study designs regarding chloroquine and HCQ we have seen. © 2020 American Association for the Advancement of Science.
Disgustingly rotten is more like it. Fevers are broken within 24 HOURS. Available at: Emergency doctor working in the community.
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