0000002834 00000 n 0000007234 00000 n The coefficients of most clinical relevance are the blood:gas and oil:gas partition coefficients.
A partition coefficient is simply the ratio of the concentration of anesthetic in one phase or solvent compared to another.
1136 32
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the partition coefficient). %PDF-1.5 %���� 0000006831 00000 n FORMULA conc.
��+J�u�Mj&)J�*��k�@��f)�}�GQ��jKϊ�+������7Ke��1-$�'�S.>/����,�X�ܸ=�\�h��������M�?�]�=ݜ��B�V�)?.^, zBo�i4m)�2��@�=��Q��D�b�h�E�&5�"�j�m�,he��;�9�ܚ �_�)�F��,����E�P洖ُ������@��+ȥ;�-8t�ã?����ֻ�4�6����Z���k�,��u�F�j)*+5�� �@�Z��\V�CM�#X�x����1y!�+��D��Ʌ��� ύ�l�L��E 6;g��ض�d�Y����wW�*��{�pڛ[�tK̏"��a��T�yѩ�Ŵh��6��:��^#�]�5^[oBj�6��L�h���u�R������>���i��E�UՐ Using this phenocryst-matrix approach, Onuma et al. The partition coefficient, abbreviated P, is defined as a particular ratio of the concentrations of a solute between the two solvents (a biphase of liquid phases), specifically for un-ionized solutes, and the logarithm of the ratio is thus log P. When one of the solvents is water and the other is a non-polar solvent, then the log P value is a measure of lipophilicity or hydrophobicity. Distribution coefficient 0000076515 00000 n 1 0 obj
0000007326 00000 n
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0000002366 00000 n �Y�� 3}��y�n��;6t�Ί���q�9'�5��r���}Ԥp֝�iw [�q�Bc��̦����o�;��b�˧��|v�;c�N���np�͙;3 潵��S��k����c��9�t�� �Tx�]N�9
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0000002834 00000 n 0000007234 00000 n The coefficients of most clinical relevance are the blood:gas and oil:gas partition coefficients.
A partition coefficient is simply the ratio of the concentration of anesthetic in one phase or solvent compared to another.
1136 32
%%EOF 0000004195 00000 n 0000003387 00000 n <>stream Sometimes a value is calculated - from knowledge of the molecular structure - rather that determined experimentally. 0000133773 00000 n 0000006598 00000 n 0000003849 00000 n
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the partition coefficient). %PDF-1.5 %���� 0000006831 00000 n FORMULA conc.
��+J�u�Mj&)J�*��k�@��f)�}�GQ��jKϊ�+������7Ke��1-$�'�S.>/����,�X�ܸ=�\�h��������M�?�]�=ݜ��B�V�)?.^, zBo�i4m)�2��@�=��Q��D�b�h�E�&5�"�j�m�,he��;�9�ܚ �_�)�F��,����E�P洖ُ������@��+ȥ;�-8t�ã?����ֻ�4�6����Z���k�,��u�F�j)*+5�� �@�Z��\V�CM�#X�x����1y!�+��D��Ʌ��� ύ�l�L��E 6;g��ض�d�Y����wW�*��{�pڛ[�tK̏"��a��T�yѩ�Ŵh��6��:��^#�]�5^[oBj�6��L�h���u�R������>���i��E�UՐ Using this phenocryst-matrix approach, Onuma et al. The partition coefficient, abbreviated P, is defined as a particular ratio of the concentrations of a solute between the two solvents (a biphase of liquid phases), specifically for un-ionized solutes, and the logarithm of the ratio is thus log P. When one of the solvents is water and the other is a non-polar solvent, then the log P value is a measure of lipophilicity or hydrophobicity. Distribution coefficient 0000076515 00000 n 1 0 obj
0000007326 00000 n
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0000002366 00000 n �Y�� 3}��y�n��;6t�Ί���q�9'�5��r���}Ԥp֝�iw [�q�Bc��̦����o�;��b�˧��|v�;c�N���np�͙;3 潵��S��k����c��9�t�� �Tx�]N�9
Sagar Kishor Savale
of Drug in org. 0 Un랃�b�˨)�Wj�o� sZ1�f�H���8��~�U|�3fn:�
0000002834 00000 n 0000007234 00000 n The coefficients of most clinical relevance are the blood:gas and oil:gas partition coefficients.
A partition coefficient is simply the ratio of the concentration of anesthetic in one phase or solvent compared to another.
1136 32
%%EOF 0000004195 00000 n 0000003387 00000 n <>stream Sometimes a value is calculated - from knowledge of the molecular structure - rather that determined experimentally. 0000133773 00000 n 0000006598 00000 n 0000003849 00000 n
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the partition coefficient). %PDF-1.5 %���� 0000006831 00000 n FORMULA conc.
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0000007326 00000 n
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0000002366 00000 n �Y�� 3}��y�n��;6t�Ί���q�9'�5��r���}Ԥp֝�iw [�q�Bc��̦����o�;��b�˧��|v�;c�N���np�͙;3 潵��S��k����c��9�t�� �Tx�]N�9
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1 0 obj 1136 0 obj <> endobj
table of contents page 1.0 introduction and background ..... 1-1 2.0 literature survey for metal partition coefficients ..... 2-1