There are no adequate and well-controlled studies of promethazine in pregnant women. I guess it's OK if you're able to sleep all day. Use sunscreen and wear protective clothing when outdoors. Available for Android and iOS devices. Administration of dextromethorphan may be accompanied by histamine release and should be used with caution in atopic children. Antihistamines are contraindicated for use in the treatment of lower respiratory tract symptoms, including asthma.
Signs and symptoms of overdosage with promethazine HCl range from mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.
These could be early signs of dangerous side effects.
Convulsions may rarely occur. Do not use a household spoon because you may not get the correct dose. The duration of action after oral administration is approximately three to six hours. Since recurrences of NMS have been reported with phenothiazines, the reintroduction of promethazine HCl should be carefully considered. What conditions does Promethazine-DM treat? Animal reproduction studies have not been conducted with the drug combination–promethazine and dextromethorphan. Pregnancy Tests: Diagnostic pregnancy tests based on immunological reactions between HCG and anti-HCG may result in false-negative or false-positive interpretations. IT IS RECOMMENDED THAT THE LOWEST EFFECTIVE DOSE OF PROMETHAZINE HYDROCHLORIDE BE USED IN PEDIATRIC PATIENTS 2 YEARS OF AGE AND OLDER AND CONCOMITANT ADMINISTRATION OF OTHER DRUGS WITH RESPIRATORY DEPRESSANT EFFECTS BE AVOIDED. Enter the shape, color, or imprint of your prescription or OTC drug. Copyright 1996-2018 Cerner Multum, Inc. POSTMARKETING CASES OF RESPIRATORY DEPRESSION, INCLUDING FATALITIES, HAVE BEEN REPORTED WITH USE OF PROMETHAZINE HYDROCHLORIDE IN PEDIATRIC PATIENTS LESS THAN 2 YEARS OF AGE. Discuss the risks and benefits with your doctor.
Different brands of this medication have different storage needs. Promethazine:CNS Depressants – Promethazine may increase, prolong, or intensify the sedative action of other central nervous system depressants, such as alcohol, sedatives/hypnotics (including barbiturates), narcotics, narcotic analgesics, general anesthetics, tricyclic antidepressants, and tranquilizers; therefore, such agents should be avoided or administered in reduced dosage to patients receiving promethazine HCl. Set goals and get tips with our app. Tell your doctor right away if any of these unlikely but serious side effects occur: decreased coordination, difficulty urinating, shaking (tremor). Lower Seizure Threshold Promethazine is a phenothiazine derivative which differs structurally from the antipsychotic phenothiazines by the presence of a branched side chain and no ring substitution. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Indications for Promethazine DM: Cough and upper respiratory symptoms associated with allergy and common cold. THE USE OF PROMETHAZINE PRODUCTS SHOULD BE AVOIDED IN PEDIATRIC PATIENTS WHOSE SIGNS AND SYMPTOMS MAY SUGGEST REYE'S SYNDROME OR OTHER HEPATIC DISEASES. The effect on later growth and development of the newborn is unknown. Going back to doc's to ask for something else! Data sources include IBM Watson Micromedex (updated 1 Oct 2020), Cerner Multum™ (updated 1 Oct 2020), Wolters Kluwer™ (updated 30 Sep 2020) and others. Other important considerations in the differential diagnosis include central anticholinergic toxicity, heat stroke, drug fever and primary central nervous system (CNS) pathology. found this review helpful. ANTIEMETICS ARE NOT RECOMMENDED FOR TREATMENT OF UNCOMPLICATED VOMITING IN PEDIATRIC PATIENTS, AND THEIR USE SHOULD BE LIMITED TO PROLONGED VOMITING OF KNOWN ETIOLOGY. Available for Android and iOS devices. found this review helpful. When given concomitantly with promethazine, the dose of barbiturates should be reduced by at least one-half, and the dose of narcotics should be reduced by one-quarter to one-half. Had persistent cough, headache, fever, chills and fatigue with some congestion. Promethazine with DM drug interactions (in more detail). If any of these effects persist or worsen, notify your doctor or pharmacist promptly. Avoid drinking alcohol. Promethazine and dextromethorphan should be given to a pregnant woman only if clearly needed. person It is not known whether this drug combination can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Promethazine hydrochloride occurs as a white to faint yellow, practically odorless, crystalline powder which slowly oxidizes and turns blue on prolonged exposure to air. This is not a complete list of possible side effects. If you take certain products together you may accidentally take too much of one or more types of medicine. Sedating drugs may cause confusion and over-sedation in the elderly; elderly patients generally should be started on low doses of promethazine hydrochloride and dextromethorphan hydrobromide oral solution and observed closely. Consult your doctor before breast-feeding. Promethazine and dextromethorphan may cause marked drowsiness or impair the mental and/or physical abilities required for the performance of potentially hazardous tasks, such as driving a vehicle or operating machinery. Data sources include IBM Watson Micromedex (updated 1 Oct 2020), Cerner Multum™ (updated 1 Oct 2020), Wolters Kluwer™ (updated 30 Sep 2020) and others. I stopped the cough syr These doses are from approximately 2.1 to 4.2 times the maximum recommended total daily dose of promethazine for a 50-kg subject, depending upon the indication for which the drug is prescribed. Last updated on Sep 1, 2019. Promethazine should be used cautiously in persons with cardiovascular disease or with impairment of liver function.
Consideration should be given to the discontinuation of promethazine HCl and to the use of other drugs if these reactions occur. Drug, supplement, and vitamin information on the go. Before having surgery or procedures such as X-rays with dye, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Your pharmacist has information about Promethazine with DM written for health professionals that you may read. Keep taking Promethazine with DM and talk with your doctor if you have any of these less serious side effects: dizziness, drowsiness, sleepiness, or confusion; Side effects other than those listed here may also occur. The management of NMS should include 1) immediate discontinuation of promethazine HCl, antipsychotic drugs, if any, and other drugs not essential to concurrent therapy, 2) intensive symptomatic treatment and medical monitoring, and 3) treatment of any concomitant serious medical problems for which specific treatments are available. What should I know regarding pregnancy, nursing and administering Promethazine-DM to children or the elderly? There is no general agreement about specific pharmacological treatment regimens for uncomplicated NMS. Diazepam may be used to control convulsions. We comply with the HONcode standard for trustworthy health information -, Drug class: upper respiratory combinations. Neuroleptic malignant syndrome (potentially fatal) has also been reported. Dextromethorphan should not be used in patients receiving a monoamine oxidase inhibitor (MAOI) (see PRECAUTIONS, Drug Interactions). promethazine-dm 1 … (See WARNINGS – Promethazine; Respiratory Depression. Dextromethorphan is metabolized primarily by liver enzymes undergoing O-demethylation, N-demethylation, and partial conjugation with glucuronic acid and sulfate. I still have the cough. Stop using Promethazine with DM and call your doctor at once if you have any of these serious side effects: uncontrollable movements of your eyes, lips, tongue, face, arms, or legs; tremors, twitching, or uncontrolled muscle movements in your face, arms, or legs. However, it may have undesirable effects on a nursing infant. What's That Rash? Fight allergies with daily forecasts, local alerts, and personalized tips. It has kept me up ALL NIGHT LONG. Promethazine and dextromethorphan should be used during pregnancy only if the potential benefit justifies the risk to the fetus.
Do not drive, use machinery, or do anything that needs alertness or clear vision until you can do it safely. A WIDE RANGE OF WEIGHT-BASED DOSES OF PROMETHAZINE HYDROCHLORIDE HAVE RESULTED IN RESPIRATORY DEPRESSION IN THESE PATIENTS.
I am up all night and all day still coughing”, For Cough: “Had severe bronchitis and non stop cough for over 2 weeks. It is used to help motion sickness. The fluid will help loosen the mucus in your lungs. Read user comments about the side effects, benefits, and effectiveness of promethazine-DM oral. Gastrointestinal – Dry mouth, nausea, vomiting, jaundice. If you are prescribed this medication on a regular schedule and miss a dose, take it as soon as you remember. WebMD does not provide medical advice, diagnosis or treatment. Limited data suggest that use of promethazine HCl during labor and delivery does not have an appreciable effect on the duration of labor or delivery and does not increase the risk of need for intervention in the newborn. US residents can call their local poison control center at 1-800-222-1222. Thus, concomitant administration of promethazine with dextromethorphan and MAO inhibitors should be avoided (see CONTRAINDICATIONS). Respiratory Depression: Promethazine may lead to potentially fatal respiratory depression. Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]. There is no general agreement about specific pharmacological treatment regimens for uncomplicated NMS. The drug acts centrally and elevates the threshold for coughing. Dosage Form: oral syrup. I still have the cough. Since recurrences of NMS have been reported with phenothiazines, the reintroduction of promethazine HCl should be carefully considered. PROMETHAZINE HYDROCHLORIDE SHOULD NOT BE USED IN PEDIATRIC PATIENTS LESS THAN 2 YEARS OF AGE BECAUSE OF THE POTENTIAL FOR FATAL RESPIRATORY DEPRESSION. Do not take extra medicine to make up the missed dose.
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